Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence.

  title={Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence.},
  author={Ilaria Grizzi and Henri Garreau and Sirius Li and Michel Vert},
  volume={16 4},
The hydrolytic degradation of aliphatic polyesters derived from lactic and glycolic acids (PLA/GA polymers) has been previously shown to proceed heterogeneously in the case of large size devices, the rate of degradation being greater inside than at the surface. A qualitative model based on diffusion-reaction phenomena was proposed which accounts for the formation of the more stable outer layer. However, this model also suggested that devices with dimensions smaller than the thickness of the… CONTINUE READING
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