Hydrolytic cationic ester microparticles for highly efficient DNA vaccine delivery.

@article{Zhang2013HydrolyticCE,
  title={Hydrolytic cationic ester microparticles for highly efficient DNA vaccine delivery.},
  author={Lei Zhang and Andrew Sinclair and Zhiqiang Cao and Jean-Rene Ella-Menye and Xuewei Xu and Louisa R Carr and Suzie H Pun and Shaoyi Jiang},
  journal={Small},
  year={2013},
  volume={9 20},
  pages={3439-44}
}
DNA vaccination holds great potential to be a safer and more efficient alternative to traditional vaccination strategies, but the current lack of nontoxic and effective delivery systems is the greatest impediment to its clinical implementation. In this work, a convenient one-step method is used to prepare a degradable "microgel" delivery platform, featuring hydrolytic esters. Prior to hydrolysis, these micrometer-sized gel particles can effectively condense DNA due to their positive surface… CONTINUE READING