Hydrolysis rates of pyrrolizidine alkaloids derived from Senecio jacobaea

  title={Hydrolysis rates of pyrrolizidine alkaloids derived from Senecio jacobaea},
  author={Stephen R. Dueker and Michael W. Lam{\'e} and Henry J Segall},
  journal={Archives of Toxicology},
Many of the commonly studied pyrrolizidine alkaloids (PAs) are built upon the subgroup retronecine (RET), which is released from the parent molecule by either base catalyzed or enzymatic hydrolysis of the ester linkages. The rate of appearance of RET in a hydrolytic study would thus reflect the rate of hydrolysis for the PA being tested. We have developed a gas chromatographic (GC) method to measure the release of RET from incubations of PAs with the guinea pig carboxylesterase, GPH1. The PAs… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 13 references

1988b) Determinations of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry

  • CK Winter, H JSegall, AD Jones
  • Biomed Environ Mass Spectrom
  • 1988

Chemistry and toxicology of pyrrolizidine alkaloids

  • AR Mattocks
  • 1986
2 Excerpts

Mechanisms of pyrrolizidine alkaloid toxicity

  • AR Mattocks
  • 1973

Similar Papers

Loading similar papers…