Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.

@article{Neidlinger2006HydrolysisOP,
  title={Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.},
  author={Nikole A. Neidlinger and Sandra K. Larkin and Amrita Bhagat and Gregory P. Victorino and Frans A. Kuypers},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 2},
  pages={
          775-81
        }
}
Secretory phospholipase A(2) (sPLA(2)) type IIa, elevated in inflammation, breaks down membrane phospholipids and generates arachidonic acid. We hypothesized that sPLA(2) will hydrolyze red blood cells that expose phosphatidylserine (PS) and generate lysophosphatidic acid (LPA) from phosphatidic acid that is elevated in PS-exposing red blood cells. In turn, LPA, a powerful lipid mediator, could affect vascular endothelial cell function. Although normal red blood cells were not affected by sPLA… CONTINUE READING
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