Hydrolysis of exogenous substrates by mitochondrial phospholipase A2.

  title={Hydrolysis of exogenous substrates by mitochondrial phospholipase A2.},
  author={Hans Lenting and F. W. Neys and Han van den Bosch},
  journal={Biochimica et biophysica acta},
  volume={917 1},
Evidence is provided in this paper to indicate that hydrolysis of exogenously added phosphatidylethanolamine and phosphatidylcholine by the membrane-bound phospholipase A2 from rat-liver mitochondria is preceded by association of the substrates with the membranes. Hydrolysis of phosphatidylethanolamine after preincubation of mitochondria and substrate is nearly independent of incubation volume, indicating that substrate and mitochondria are not independently diluted. The association is greatly… CONTINUE READING