Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin.

@article{Mitchell2015HydrolysisOA,
  title={Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin.},
  author={Shannon Mary Mitchell and Jeffrey Layton Ullman and Andrew R. Teel and Richard J. Watts},
  journal={Chemosphere},
  year={2015},
  volume={134},
  pages={
          504-11
        }
}
Antibiotics that enter the environment can present human and ecological health risks. An understanding of antibiotic hydrolysis rates is important for predicting their environmental persistence as biologically active contaminants. In this study, hydrolysis rates and Arrhenius constants were determined as a function of pH and temperature for two amphenicol (chloramphenicol and florfenicol) and two macrolide (spiramycin and tylosin) antibiotics. Antibiotic hydrolysis rates in pH 4-9 buffer… CONTINUE READING
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