Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes.

@article{Ren1998HydrolysisOG,
  title={Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes.},
  author={M. Ren and G. Xu and J. Zeng and C. De Lemos-Chiarandini and M. Adesnik and D. Sabatini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={
          6187-92
        }
}
  • M. Ren, G. Xu, +3 authors D. Sabatini
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Rab11 is a small GTP-binding protein that in cultured mammalian cells has been shown to be concentrated in the pericentriolar endosomal recycling compartment and to play a key role in passage of the recycling transferrin receptor through that compartment [Ullrich, O., Reinsch, S., Urbé, S., Zerial, M. & Parton, R. G. (1996) J. Cell Biol. 135, 913-924]. To obtain insights into the site(s) of action of rab11 within the recycling pathway, we have now compared the effects on recycling at 37… Expand
Rab22a Regulates the Sorting of Transferrin to Recycling Endosomes
TLDR
It is speculated that Rab22a controls the transport of the transferrin receptor from sorting to recycling endosomes and depletion by small interfering RNA disorganized the perinuclear recycling center and strongly inhibited transferrin recycling. Expand
Rab 11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the trans-Golgi Network
Several GTPases of the Rab family, known to be regulators of membrane traffic between organelles, have been described and localized to various intracellular compartments. Rab11 has previously beenExpand
Rab11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the Trans-Golgi Network
TLDR
The results suggest that Rab11 influences endosome to TGN trafficking primarily by regulating membrane distribution inside the early endosomal pathway. Expand
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TLDR
It is concluded that functional Rab11b is essential for the transport of internalized transferrin from the recycling compartment to the plasma membrane. Expand
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TLDR
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TLDR
It is shown that transport is temperature-, energy-, and time-dependent and requires the presence of Rab proteins, as it is inhibited by the Rab-interacting protein Rab GDP-dissociation inhibitor that removes Rab proteins from the membrane. Expand
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TLDR
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Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway.
TLDR
The protein composition of Rab5- and Rab11-carrying endosomes is analysed to gain further insight into the compartmental organization of the endocytic and recycling pathway, and data suggest an organizations of the transferrin pathway into distinct Rab 5- andrab11-positive compartments. Expand
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TLDR
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Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size
TLDR
The results implicate Syt III as a critical factor for the generation and delivery of internalized cargo to the perinuclear endocytic recycling compartment and suggest a possible link between ERC and recycling from immature SGs during the process of SG maturation. Expand
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It is shown that MPRs are limiting in the secretory pathway of cells expressing rab9 S21N and the importance of MPR recycling and the rab9 GTPase for efficient lysosomal enzyme delivery is documented. Expand
Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.
TLDR
The pathway of Tfn receptor recycling consists of at least two biochemically and functionally distinct populations of endosomes, a Rab4-positive population of early endosome to which incoming Tfn is initially delivered and a Rab 4-negative population of recycling vesicles that transiently accumulates Tfn on its route back to the plasma membrane. Expand
Rab11 regulates recycling through the pericentriolar recycling endosome
TLDR
A novel role for rab11 in controlling traffic through the recycling endosome is suggested after functional studies showed that the early steps of uptake and recycling for transferrin were not affected by overexpression of rab11 proteins. Expand
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TLDR
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