Corpus ID: 23788954

Hydrolysis of 2,4-dithiophenobarbital.

@article{Tarsa2009HydrolysisO2,
  title={Hydrolysis of 2,4-dithiophenobarbital.},
  author={Monika Tarsa and G. Żuchowski and A. Stasiewicz-Urban and J. Bojarşki},
  journal={Acta poloniae pharmaceutica},
  year={2009},
  volume={66 2},
  pages={
          123-8
        }
}
Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2-12 was investigated at 40 and 60 degrees C using UV spectrophotometry. The values of reaction order, rate constants, pKa1 and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods. 
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