Hydrolysis mechanism of 7-acetylacroninium perchlorate, a novel prodrug of acronine.

Abstract

7-Acetylacroninium perchlorate was hydrolyzed at 25 degrees by both water enriched with 18O-labeled water and by unenriched water. The acronine obtained was examined by mass spectrometry, which indicated the unusual fact that hydrolysis of this ester proceeded by aryl oxygen cleavage to the extent of about 30% under those mild conditions.

Cite this paper

@article{Repta1977HydrolysisMO, title={Hydrolysis mechanism of 7-acetylacroninium perchlorate, a novel prodrug of acronine.}, author={Arnold J. Repta and Jonathan R. Dimmock and Bo Kreilg{\aa}rd and James Kaminski}, journal={Journal of pharmaceutical sciences}, year={1977}, volume={66 10}, pages={1501-3} }