Hydrolysis kinetics of diacetyl nadolol.

C. Chiang; C. Wu; H. Huang

DOI:10.1002/JPS.2600761215

Corpus ID: 21011078

Hydrolysis kinetics of diacetyl nadolol.

@article{Chiang1987HydrolysisKO,
  title={Hydrolysis kinetics of diacetyl nadolol.},
  author={C. Chiang and C. Wu and H. Huang},
  journal={Journal of pharmaceutical sciences},
  year={1987},
  volume={76 12},
  pages={
          914-7
        }
}

C. Chiang, C. Wu, H. Huang

Published 1987

Chemistry, Medicine

Journal of pharmaceutical sciences

Diacetyl nadolol, a prodrug of nadolol and a beta-blocker, has corneal permeability approximately 20 times higher than that of its parent compound due to its higher lipophilicity. Hydrolysis studies were conducted for diacetyl nadolol at various elevated temperatures and pH values to provide stability information for its ophthalmic preparations. The apparent rate constants for diacetyl nadolol hydrolysis to acetyl nadolols and nadolol were determined. Within the neutral pH range (6.8 to 8.2… CONTINUE READING

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