Hydrolysis by plasma kallikrein of fluorogenic peptides derived from prorenin processing site.

@article{Almeida2000HydrolysisBP,
  title={Hydrolysis by plasma kallikrein of fluorogenic peptides derived from prorenin processing site.},
  author={Paulo C{\'e}sar Andrade Almeida and Jair Ribeiro Chagas and Maria Helena Sedenho Cezari and Maria Aparecida Juliano and Luiz Juliano},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1479 1-2},
  pages={
          83-90
        }
}
Human plasma kallikrein (HPK) activates plasma prorenin to renin, and the physiological significance of this activation is still unknown. In this paper we investigated the efficiency and the cleavage pattern of the hydrolysis by HPK of the internally quenched fluorescent peptides (qf-peptides) derived from the amino acid sequence of human prorenin cleavage site. The peptide Abz-F-S-Q-P-M-K-R-L-T-L-G-N-T-T-Q-EDDnp (Abz=ortho-aminobenzoic acid, and EDDnp=N-[2,4-dinitrophenyl]-ethylene diamine… CONTINUE READING
BETA