Hydrolysis and protein binding of melphalan.

  title={Hydrolysis and protein binding of melphalan.},
  author={Sai Y. Chang and David S. Alberts and David Farquhar and L R Melnick and Philip D. Walson and Sydney Salmon},
  journal={Journal of pharmaceutical sciences},
  volume={67 5},
Melphalan (30 microgram/ml) is completely hydrolyzed in water at 37 degrees after 8 hr. At lower temperatures, hydrolysis proceeds at slower rates. The presence of bovine serum albumin retards hydrolysis of melphalan (30 microgram/ml) in water. The melphalan hydrolysis rate is directely releated to the bovine serum albumin concentration. At 37 degrees, 8 g of bovine serum albumin/100 ml of water gives a recovery rate of melphalan similar to that of human plasma. In vitro alkylation of melphalan… CONTINUE READING

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