Hydrolase regulates NAD+ metabolites and modulates cellular redox.

  title={Hydrolase regulates NAD+ metabolites and modulates cellular redox.},
  author={Lei Tong and Susan Lee and John M Denu},
  journal={The Journal of biological chemistry},
  volume={284 17},
Although the classical redox functions of co-enzyme NAD(+) are firmly established in metabolism, there are numerous enzymes that catalyze cleavage of NAD(+) to yield free ADP-ribose (ADPr) or related metabolites, whose functions remain largely unknown. Here we show that the Nudix (nucleoside diphosphate linked to another moiety X) hydrolase Ysa1 from Saccharomyces cerevisiae is a major regulator of cellular ADPr and O-acetyl-ADP-ribose (OAADPr). OAADPr is the direct product of NAD(+)-dependent… CONTINUE READING


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