Hydrogen tunneling links protein dynamics to enzyme catalysis.

@article{Klinman2013HydrogenTL,
  title={Hydrogen tunneling links protein dynamics to enzyme catalysis.},
  author={Judith P Klinman and Amnon Kohen},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={
          471-96
        }
}
The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and verify. Here, we show how the quantum mechanical hydrogen tunneling associated with enzymatic C-H bond cleavage provides a unique window into the necessity of protein dynamics for… CONTINUE READING
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