Hydrogen tunneling links protein dynamics to enzyme catalysis.

@article{Klinman2013HydrogenTL,
  title={Hydrogen tunneling links protein dynamics to enzyme catalysis.},
  author={J. Klinman and A. Kohen},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={
          471-96
        }
}
  • J. Klinman, A. Kohen
  • Published 2013
  • Chemistry, Medicine
  • Annual review of biochemistry
  • The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and verify. Here, we show how the quantum mechanical hydrogen tunneling associated with enzymatic C-H bond cleavage provides a unique window into the necessity of protein dynamics for… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Linking Protein Motion to Enzyme Catalysis
    16
    Protein-like proton exchange in a synthetic host cavity
    12

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 154 REFERENCES
    Relating protein motion to catalysis.
    468
    Good vibrations in enzyme-catalysed reactions.
    188