Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.

BACKGROUND AND PURPOSE Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly concerning is the lack of effective preventative or curative treatments for NSAID-induced intestinal damage and… CONTINUE READING