Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function.

@article{Srilatha2007HydrogenSA,
  title={Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function.},
  author={Balasubramanian Srilatha and P. Ganesan Adaikan and Ling Li and Philip Keith Moore},
  journal={The journal of sexual medicine},
  year={2007},
  volume={4 5},
  pages={
          1304-11
        }
}
INTRODUCTION In a pilot study, we found that the novel gasotransmitter, hydrogen sulfide (H2S), had a vasodilatory and proerectile action on the cavernosum. In the present work, we explored the ability of the cavernosum to synthesize H2S and its mechanism on the cavernosal pathways. AIM To evaluate the physiopharmacological responses and mechanism in the erectile function of H2S in rabbit cavernosum. METHODS Rabbit corpus cavernosum (CC) smooth muscle tissue (N = 5) was homogenized and… Expand
Potassium channels modulate the action but not the synthesis of hydrogen sulfide in rat corpus cavernosum
TLDR
H2S‐induced relaxation of rat corpus cavernosum may be mediated through BKca and KV channels not by KATP and Kir channels, and it also seems that K+‐channels do not contribute to the synthesis of H2S. Expand
Resveratrol Stimulates Hydrogen Sulfide (H2 S) Formation to Relax Murine Corpus Cavernosum.
TLDR
Results demonstrate that RVT-induced relaxation is at least partly dependent on H2 S formation and acts independent of eNOS pathway and in phosphodiesterase 5 inhibitor (PDE-5i) nonresponder population, combination therapy with RVT may reverse erectile dysfunction via stimulating endogenous H 2 S formation. Expand
Hydrogen sulfide and erectile function: a novel therapeutic target
TLDR
The L-cysteine–H2S pathway may represent a promising target for development of new therapeutics for erectile dysfunction and its role in physiological control of penile tone is demonstrated. Expand
Overview of potential molecular targets for hydrogen sulfide: A new strategy for treating erectile dysfunction.
TLDR
This review examines the mechanisms of the role of H2S in the physiology of erection, and how it may be applied in the future to the treatment of men with multiple comorbidities and ED. Expand
Analysis of erectile responses to H2S donors in the anesthetized rat.
TLDR
Erectile responses to Na2S are mediated by a tetraethylammonium- and iberiotoxin-sensitive mechanism and that KATP channels, NO, or arachidonic acid metabolites are not involved and it is suggested that strategies that increase H2S formation in penile tissue may be useful in the treatment of erectile dysfunction when NO bioavailability, KatP channel function, or poor responses to PGE1 are present. Expand
Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosum.
TLDR
H2S plays a compensatory role in the absence of NO by enhancing the relaxation induced by endogenous H2S through CSE and 3-MPST in MCC, without altering downstream mechanisms, and it is suggested that H 2S-targeting drugs may provide the maintenance of compensatory treatment in ED patients. Expand
Role of hydrogen sulfide in the physiology of penile erection.
TLDR
This review intends to present the H( 2)S pathway in penile tissue and the potential role of H(2)S in the physiology of erections to provide alternative erectile dysfunction strategies for those patients with poor or no response to type 5 phosphodiesterase inhibitors. Expand
Hydrogen Sulfide and Urogenital Tract.
TLDR
The H2S pathway is not only involved in penile erection but also plays a role in bladder homeostasis and the finding that it involved in the mechanism of action of PDE-5 inhibitors strongly suggests that modulation of this pathway can represent a therapeutic target for the treatment of erectile dysfunction and bladder diseases. Expand
Initial characterization of hydrogen sulfide effects in female sexual function.
TLDR
These pilot studies clearly indicate the smooth muscle relaxant effect of H(2)S in female genital tract, mediating through cyclic adenosine 3':5'-monophosphate, nitric oxide-cyclic guanosine monoph phosphate and K(+)(ATP) channels. Expand
Role of endogenous hydrogen sulfide in neurogenic relaxation of rat corpus cavernosum.
TLDR
Using physiologically relevant concentrations of exogenous NaHS, it is shown that nanomolar concentrations could inhibit corporal relaxation induced by a nitroxyl (HNO) donor (Angeli's salt) but not with nitrosonium (NO(+)) or NO donors, which suggests that an interaction between endogenously produced H(2)S and nitoxyl ( HNO) might be involved in erectile function. Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating KATP Channels
TLDR
Data show that H2S inhibits nociception induced by CRD in both healthy and postcolitic rats, and this effect is mediated by KATP channels and NO. Expand
Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study.
TLDR
A possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence is suggested and the inhibitory effect of propargylglycine on the proerectile pathway is confirmed. Expand
[Hydrogen sulfide as a biologically active mediator in the cardiovascular system].
  • J. Bełtowski
  • Medicine, Chemistry
  • Postepy higieny i medycyny doswiadczalnej
  • 2004
TLDR
Reduced H2S generation has been demonstrated in the vasculature of spontaneously hypertensive rat, in experimental hypertension induced by NO synthase blockade, and in hypoxia-induced pulmonary hypertension, and administration of exogenous H1N1 donor has significant therapeutic effects in these models. Expand
Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system.
TLDR
H(2)S is a new endogenous gaseous transmitter in the cardiovascular system and exerts regulatory effects on the pathogenesis of various cardiovascular diseases such as hypertension, pulmonary hypertension, shock and myocardial injury. Expand
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide.
TLDR
These findings provide the first evidence for the formation of a novel nitrosothiol generated by reaction between H2S and *NO, and it is proposed that generation of this nitrosothsiol in the body may regulate the physiological effects of both *NO and H2s. Expand
Hydrogen sulfide as a neuromodulator
  • H. Kimura
  • Biology, Medicine
  • Molecular Neurobiology
  • 2007
TLDR
H2S is produced in response to neuronal excitation, and alters hippocampal long-term potentiation (LTP), a synaptic model for memory, and can also regulate the release of corticotropin-releasing hormone from hypothalamus. Expand
The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility
TLDR
Results show that NaHS relaxes gastrointestinal and urogenital smooth muscle and suggest that H2S is responsible for these effects and show that guinea‐pig ileum to field stimulation is affected. Expand
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes.
TLDR
Findings provide the first evidence that H2S may protect the heart most probably by activating sarcolemmal KATP channels and/or provoking NO release and the cardioprotective effects of metabolic ischemic preconditioning is, at least partially, mediated by endogenous H1N1. Expand
The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.
TLDR
The results showed that endogenous H(2)S system was involved in both the maintenance of basal blood pressure and the development of hypertension, and could exert beneficial effect on the pathogenesis of spontaneous hypertension. Expand
Hydrogen sulfide as a vasodilator
TLDR
CSE is believed to be the key enzyme which forms H2S in the cardiovascular system, which has been shown to exhibit potent vasodilator activity both in vitro and in vivo most probably by opening vascular smooth muscle KATP channels. Expand
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