Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.

@article{Suzuki2011HydrogenSR,
  title={Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.},
  author={Kunihiro Suzuki and G{\'a}bor Ol{\'a}h and Katalin M{\'o}dis and Ciro Coletta and Gabriella Kulp and Domokos Ger{\"o} and Petra Szoleczky and Tuanjie Chang and Zongmin Zhou and Ling-Yun Wu and Rui Wang and Andreas Papapetropoulos and Csaba Szab{\'o}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 33},
  pages={13829-34}
}
The goal of the present studies was to investigate the role of changes in hydrogen sulfide (H(2)S) homeostasis in the pathogenesis of hyperglycemic endothelial dysfunction. Exposure of bEnd3 microvascular endothelial cells to elevated extracellular glucose (in vitro "hyperglycemia") induced the mitochondrial formation of reactive oxygen species (ROS), which resulted in an increased consumption of endogenous and exogenous H(2)S. Replacement of H(2)S or overexpression of the H(2)S-producing… CONTINUE READING

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Low levels of hydrogen sul fi de in the blood of diabetes patients and streptozotocintreated rats causes vascular in fl ammation ?

  • SK Jain
  • Antioxid Redox Signal
  • 2010

Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal 12:1333–1337

  • SK Jain
  • 2010

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