Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx.

@article{Mikami2011HydrogenSP,
  title={Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx.},
  author={Yoshinori Mikami and Norihiro Shibuya and Yuka Kimura and Noriyuki Nagahara and Masahiro Yamada and Hideo Kimura},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 45},
  pages={39379-86}
}
Hydrogen sulfide (H(2)S) has recently been recognized as a signaling molecule as well as a cytoprotectant. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are well-known as H(2)S-producing enzymes. We recently demonstrated that 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT) produces H(2)S in the brain and in vascular endothelium. However, the cellular distribution and regulation of these enzymes are not well understood. Here we show that… CONTINUE READING