Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia.

  title={Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia.},
  author={Yali Wang and Jia Jia and Gui-zhen Ao and Lifang Hu and Hui Liu and Yunqi Xiao and Huaping Du and Nabil J. Alkayed and Chunfeng Liu and Jian Cheng},
  journal={Journal of neurochemistry},
  volume={129 5},
By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H2 S donors at 3 h after reperfusion. Infarction, neurological scores, brain edema, Evans blue (EB) extravasation, and tight junction protein expression were examined at 48 h after… CONTINUE READING
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