Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells.

  title={Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells.},
  author={Emanuela Pupo and Alessandra Fiorio Pla and Daniele Avanzato and Francesco Moccia and Jos{\'e}-Everardo Avelino Cruz and Franco Tanzi and Annalisa Merlino and Daniele Mancardi and Luca Munaron},
  journal={Free radical biology & medicine},
  volume={51 9},
Hydrogen sulfide (H(2)S) is a gasotransmitter that plays several roles in various tissues, including the cardiovascular system. Because it has been recently proposed to act as a mediator of angiogenesis progression, here we investigate the effects of H(2)S in a well-established model of tumor angiogenesis: endothelial cells obtained from human breast carcinoma (B-TECs). Ca(2+) imaging and patch-clamp experiments reveal that acute perfusion with NaHS, a widely employed H(2)S donor, activates… CONTINUE READING
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