Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.

@article{Calvert2009HydrogenSM,
  title={Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.},
  author={John W Calvert and Saurabh Jha and Susheel Gundewar and John W. Elrod and Arun Ramachandran and Christopher B Pattillo and Christopher G. Kevil and David Joseph Lefer},
  journal={Circulation research},
  year={2009},
  volume={105 4},
  pages={365-74}
}
RATIONALE The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms. OBJECTIVE The present study evaluated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacological preconditioning. METHODS AND RESULTS H(2)S (100 microg/kg) or vehicle was administered to mice via an intravenous injection 24 hours before myocardial ischemia. Treated and untreated mice… CONTINUE READING
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