Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.

  title={Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.},
  author={John W Calvert and Saurabh Jha and Susheel Gundewar and John W. Elrod and Arun Ramachandran and Christopher B Pattillo and Christopher G. Kevil and David Joseph Lefer},
  journal={Circulation research},
  volume={105 4},
RATIONALE The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms. OBJECTIVE The present study evaluated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacological preconditioning. METHODS AND RESULTS H(2)S (100 microg/kg) or vehicle was administered to mice via an intravenous injection 24 hours before myocardial ischemia. Treated and untreated mice… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
191 Citations
8 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 191 extracted citations


Publications referenced by this paper.
Showing 1-8 of 8 references

Similar Papers

Loading similar papers…