Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy

  title={Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy},
  author={Kai Song and F. M. Wang and Qian Li and Y Shi and Hui-fen Zheng and Hanjing Peng and Hua-Ying Shen and Chunfeng Liu and Li-Fang Hu},
  booktitle={Kidney international},
Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthase, a hydrogen sulfide-producing enzyme, was dramatically reduced in the ureteral obstructed kidney, but another enzyme cystathionine-γ-lyase was increased. A hydrogen sulfide donor… CONTINUE READING
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