Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.

@article{Cai2010HydrogenSI,
  title={Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.},
  author={Wen-Jie Cai and Ming-Jie Wang and Li-Hua Ju and Cheng Wang and Yi-Chun Zhu},
  journal={Cell biology international},
  year={2010},
  volume={34 6},
  pages={565-72}
}
H(2)S (hydrogen sulfide), regarded as the third gaseous transmitter, is implicated in ulcerative colitis and colorectal cancers. The present study investigates the effects of H(2)S on cell proliferation in human colon cancer HCT 116 cells and SW480 cells. We identified the two key enzymes, CBS and CSE, for H(2)S synthesis in HCT 116 cells. An exogenously administered H(2)S donor NaHS induced cell proliferation in a concentration-dependent manner, with optimal proliferative concentration at 200… CONTINUE READING

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