Hydrogen sulfide induces calcium waves in astrocytes.

  title={Hydrogen sulfide induces calcium waves in astrocytes.},
  author={Yasuo Nagai and Mamiko Tsugane and Jun-ichiro Oka and Hideo Kimura},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={18 3},
Hydrogen sulfide (H2S) modifies hippocampal long-term potentiation (LTP) and functions as a neuromodulator. Here, we show that H2S increases intracellular Ca2+ and induces Ca2+ waves in primary cultures of astrocytes as well as hippocampal slices. H2S increases the influx of Ca2+ and to a lesser extent causes the release from intracellular Ca2+ stores. Ca2+ waves induced by neuronal excitation as well as responses to exogenously applied H2S are potently blocked by La3+ and Gd3+, inhibitors of… CONTINUE READING

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