Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.

@article{Wang2015HydrogenSI,
  title={Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.},
  author={Xue-long Wang and Bin Tian and Ya Huang and Xiao-Yan Peng and Li-hua Chen and Jun-Cheng Li and Tong Liu},
  journal={Scientific reports},
  year={2015},
  volume={5},
  pages={16768}
}
The contributions of gasotransmitters to itch sensation are largely unknown. In this study, we aimed to investigate the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling. We found that intradermal injection of H2S donors NaHS or Na2S, but not GYY4137 (a slow-releasing H2S donor), dose-dependently induced scratching behavior in a μ-opioid receptor-dependent and histamine-independent manner in mice. Interestingly, NaHS induced itch via unique mechanisms that… CONTINUE READING