Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.


Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant in the brain. We recently showed that H(2)S protects neurons from oxidative stress by increasing the levels of glutathione (GSH), a major cellular antioxidant, by more than twice that of a control through enhancing the cystine transport. Here we show that H(2)S enhances the… (More)
DOI: 10.1089/ars.2008.2282