Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation.

@article{Spiller2010HydrogenSI,
  title={Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation.},
  author={Fernando Spiller and Maria I.L. Orrico and Daniele Carvalho Nascimento and Paula Giselle Czaikoski and Fabr{\'i}cio Oliveira Souto and Jose C Alves-Filho and Andressa Freitas and Daniela Carlos and M F Montenegro and Alberto Federman Neto and S{\'e}rgio Henrique Ferreira and Marcos Ant{\^o}nio Rossi and John Stephen Hothersall and Jamil Assreuy and Fernando Q Cunha},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 3},
  pages={360-8}
}
RATIONALE Recovering the neutrophil migration to the infectious focus improves survival in severe sepsis. Recently, we demonstrated that the cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) pathway increased neutrophil recruitment to inflammatory focus during sterile inflammation. OBJECTIVES To evaluate if H(2)S administration increases neutrophil migration to infectious focus and survival of mice. METHODS Sepsis was induced by cecal ligation and puncture (CLP). MEASUREMENTS AND… CONTINUE READING