Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.

@article{Liang2011HydrogenSD,
  title={Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.},
  author={Guo Hua Liang and Adebowale Adebiyi and M Dennis Leo and E. M. McNally and Charles W. Leffler and Jonathan H Jaggar},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 6},
  pages={H2088-95}
}
Hydrogen sulfide (H(2)S) is a gaseous signaling molecule that appears to contribute to the regulation of vascular tone and blood pressure. Multiple potential mechanisms of vascular regulation by H(2)S exist. Here, we tested the hypothesis that piglet cerebral arteriole smooth muscle cells generate ATP-sensitive K(+) (K(ATP)) currents and that H(2)S induces vasodilation by activating K(ATP) currents. Gas chromatography/mass spectrometry data demonstrated that after placing Na(2)S, an H(2)S donor… CONTINUE READING

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