Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

@article{Liu2016HydrogenSD,
  title={Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway},
  author={Jiaqi Liu and Jichao Wu and Aili Sun and Yu Sun and Xiangjing Yu and Ning Liu and Shiyun Dong and Fan Yang and Linxue Zhang and Xin Zhong and Changqing Xu and Fanghao Lu and Weihua Zhang},
  journal={Cell & Bioscience},
  year={2016},
  volume={6},
  pages={1-17}
}
Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on excessive autophagy of vascular endothelial cells is unclear. In this study, aorta of db/db mice (28 weeks old) and rat aortic endothelial cells (RAECs) treated with 40 mM glucose and 500 μM palmitate acted as type II diabetic animal and cellular models, respectively, and 100 μMNaHS was… CONTINUE READING