Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

@article{Liu2016HydrogenSD,
  title={Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway},
  author={Jiaqi Liu and Jichao Wu and Aili Sun and Yu Sun and Xiangjing Yu and Ning Liu and Shiyun Dong and Fan Yang and Linxue Zhang and Xin Zhong and Changqing Xu and Fanghao Lu and Weihua Zhang},
  journal={Cell & Bioscience},
  year={2016},
  volume={6}
}
  • Jiaqi Liu, Jichao Wu, +10 authors Weihua Zhang
  • Published 2016
  • Biology, Medicine
  • Cell & Bioscience
  • BackgroundExcessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on excessive autophagy of vascular endothelial cells is unclear.MethodsIn this study, aorta of db/db mice (28 weeks old) and rat aortic endothelial cells (RAECs) treated with 40 mM glucose and 500 μM palmitate acted as type II diabetic animal and cellular models, respectively… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 34 CITATIONS, ESTIMATED 57% COVERAGE

    Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2016
    2020

    CITATION STATISTICS

    • 2 Highly Influenced Citations

    • Averaged 8 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 65 REFERENCES

    Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction.

    VIEW 1 EXCERPT

    ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

    VIEW 1 EXCERPT