Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells.

@article{Liu2016HydrogenSA,
  title={Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells.},
  author={Mi-Hua Liu and Xiao-long Lin and Cong Yuan and Jun He and Tian-Ping Tan and Shao-Jian Wu and Shan Yu and Li Chen and Jun Liu and Wei Tian and Yu-dan Chen and Hong-Yun Fu and Jian Li and Yuan Zhang},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 1},
  pages={367-72}
}
Doxorubicin (DOX) is a widely used chemotherapeutic agent, which can give rise to severe cardiotoxicity, limiting its clinical use. Preliminary evidence suggests that hydrogen sulfide (H2S) may exert protective effects on DOX‑induced cardiotoxicity. Therefore, the aim of the present study was to investigate whether peroxiredoxin III is involved in the cardioprotection of H2S against DOX‑induced cardiotoxicity. The results demonstrated that DOX not only markedly induced injuries, including… CONTINUE READING

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