Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice.

@article{Han2011HydrogenSA,
  title={Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice.},
  author={Weihong Han and Zheng Dong and Christiana Dimitropoulou and Yunchao Su},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 8},
  pages={2121-34}
}
AIMS The mutual interactions between reactive oxygen species, airway inflammation, and alveolar cell death play crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). In the present study, we investigated the possibility that hydrogen sulfide (H(2)S) donor sodium hydrosulfide (NaHS) might be a novel option for intervention in COPD. RESULTS We used a mouse model of tobacco smoke (TS)-induced emphysema. Mice were injected with H(2)S donor NaHS (50 μmol/kg in 0.25 ml… CONTINUE READING

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