Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

@article{Song2013HydrogenrichWD,
  title={Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome},
  author={Guohua Song and Min Li and Hui Sang and Liying Zhang and Xiuhong Li and Shutong Yao and Yang Yu and Chuanlong Zong and Yazhuo Xue and Shucun Qin},
  journal={Journal of Lipid Research},
  year={2013},
  volume={54},
  pages={1884 - 1893}
}
We have found that hydrogen (dihydrogen; H2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H2-rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C… 
Hydrogen influences HDL-associated enzymes and reduces oxidized phospholipids levels in rats fed with a high-fat diet.
TLDR
It is suggested that H2 can be used in alleviating diseases related to lipid peroxidation due to oxidative stress by reducing the OxPLs levels through its influence on HDL-associated enzymes that can act on oxidized phospholipids.
Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline
TLDR
Findings provided direct evidence supporting the notion that CS exposure in vivo impairs plasma lipid profiles, HDL functionalities and macrophage-to-feces RCT pathway in CETP transgenic mice, all of which can be minimized by treatment of H2-saturated saline.
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
TLDR
The inhibitory effects of H(2) on the apoptosis of macrophage-derived foam cells, which take effect by suppressing the activation of the ERS pathway and by activating the Nrf2 antioxidant pathway, might lead to an improvement in atherosclerotic plaque stability.
Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.
TLDR
H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects, which highlight the potential role of H2 in the regression of hypercholesterolemia and atherosclerosis.
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
TLDR
The results suggest that vascular aging can be suppressed by HW, and senescent cells are eliminated and macrophage infiltration and Tnfα expression in the atheroma are suppressed.
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial
Purpose Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition
Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein.
TLDR
The biological activities of psoriatic lipoproteins are impaired in both HDL and LDL which may provide a link between psoriasis and cardiovas- cular disease.
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
TLDR
Findings suggest HW increases antioxidant capacity thereby reducing inflammatory responses in healthy adults, and transcriptional networks of inflammatory responses and NF-κB signaling were significantly down-regulated in the HW group.
Effects of hydrogen as adjuvant treatment for unstable angina
TLDR
Results support that hydrogen as adjuvant treatment has a beneficial effect on unstable angina and indicate hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway.
Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
TLDR
H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice and demonstrates a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice.
TLDR
It is revealed that administration of hydrogen-saturated saline decreases athero-susceptibility in apoB-containing lipoprotein and aortic atherosclerosis in apolipoprotein E knockout mice and improves HDL functionality in C57BL/6J mice.
Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters.
TLDR
Administration of hydrogen-saturated saline decreases plasma LDL cholesterol and apo B levels and improves hyperlipidemia-injured HDL functions, including the capacity of enhancing cellular cholesterol efflux and playing antioxidative properties, in high-fat diet-fed hamsters.
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
TLDR
A preferential increase in circulating concentrations of HDL particles possessing normalized antiatherogenic activity is therefore a promising therapeutic strategy for the treatment of common metabolic diseases featuring dyslipidemia, inflammation, and premature atherosclerosis.
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
TLDR
Exposure to hydrogen-rich water may have a beneficial role in prevention of type 2 diabetes mellitus and insulin resistance and four patients with IGT normalized the oral glucose tolerance test.
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.
TLDR
Consumption of H(2)-dissolved water at a saturated level (H(2-water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE(-/-)), a model of the spontaneous development of atherosclerosis.
Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels.
TLDR
Reduced plasma PLTP activity causes markedly decreased HDL lipid and apoprotein, demonstrating the importance of transfer of surface components of TRL in the maintenance of HDL levels.
Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
TLDR
Oxidized LDL exhibited a graded relationship to incident metabolic syndrome and was positively associated with being male, black, and obese—all components of the metabolic syndrome—and also with C-reactive protein.
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
TLDR
APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.
Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle
TLDR
It is demonstrated that H2 exerts metabolic effects similar to those of insulin and may be a novel therapeutic alternative to insulin in type 1 diabetes mellitus that can be administered orally.
[Hypertriglyceridemia and low HDL cholesterol as high impact factors for metabolic syndrome diagnosis in apparently healthy adults].
TLDR
The results suggested that hypertriglyceridemia and hypoalphalipoproteinemia are high impact factors for MS in adults.
...
1
2
3
4
...