Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats.

@article{Wang2011HydrogenrichSP,
  title={Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats.},
  author={Fei Wang and Guang Yu and Sui-Yi Liu and Jin-bao Li and Jia-feng Wang and Lu-Long Bo and Liren Qian and Xuejun Sun and Xiaoming Deng},
  journal={The Journal of surgical research},
  year={2011},
  volume={167 2},
  pages={e339-44}
}
BACKGROUND Recently it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals (·OH) and peroxynitrite anion (ONOO-) in vitro and exert therapeutic antioxidant activity in many diseases. This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats. METHODS A rat model of renal I/R injury was induced by 45-min occlusion of the bilateral renal pedicles and 24-h reperfusion. Physiologic… CONTINUE READING