Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3β in the DRG in rats.

@article{Zhang2014HydrogenrichSC,
  title={Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3β in the DRG in rats.},
  author={Linlin Zhang and Ruichen Shu and Chunyan Wang and Haiyun Wang and Nan Li and GuoLin Wang},
  journal={Brain research bulletin},
  year={2014},
  volume={106},
  pages={47-55}
}
BACKGROUND Although NMDAR trafficking mediated by GSK-3β involvement in transmission of pronociceptive messages in the spinal cord has been confirmed by our previous studies, whether NMDAR trafficking is implicated in peripheral sensitization remains equivocal. It is demonstrated that inflammation is associated with spinal NMDAR-containing nociceptive neurons activation and the maintenance of opioid induced pain hypersensitivity. However, whether and how hydrogen-rich saline, as an effective… CONTINUE READING