Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats.

@article{Cui2014HydrogenrichSA,
  title={Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats.},
  author={Yaomei Cui and Hao Zhang and M. H. Ji and Min Jia and Huixian Chen and Jianjun Yang and Man-Lin Duan},
  journal={The Journal of surgical research},
  year={2014},
  volume={192 2},
  pages={564-72}
}
BACKGROUND Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia-reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic effect of hydrogen-rich saline on neuronal mitochondrial injury from global cerebral I/R in rats… CONTINUE READING
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