Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.

@article{Shimizu2008HydrogenPS,
  title={Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.},
  author={Shunichi Shimizu and Toshihito Hiroi and Masakazu Ishii and Tamio Hagiwara and Teruaki Wajima and Akira Miyazaki and Yuji Kiuchi},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 4},
  pages={755-65}
}
Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthase (NOS). We previously described that hydrogen peroxide (H(2)O(2)) increases BH4 levels through the induction of GTP-cyclohydrolase I (GTPCH), which is the rate-limiting enzyme for the synthesis of BH4, in vascular endothelial cells. The aim of this study was to examine the underlying mechanism of H(2)O(2)-induced BH4 synthesis in vascular endothelial cells. The increases in BH4 levels induced by H(2)O(2) were strongly… CONTINUE READING

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