Hydrogen peroxide release from alveolar macrophages and alveolar type II cells during adaptation to hyperoxia in vivo.

@article{Kinnula1992HydrogenPR,
  title={Hydrogen peroxide release from alveolar macrophages and alveolar type II cells during adaptation to hyperoxia in vivo.},
  author={Vuokko L. Kinnula and Ling Yi Chang and Y S Ho and James D. Crapo},
  journal={Experimental lung research},
  year={1992},
  volume={18 5},
  pages={
          655-73
        }
}
The effect of hyperoxia (1-14 days, 85% O2) on rat alveolar macrophage and alveolar type II cell oxidant and antioxidant characteristics was investigated. Unstimulated control macrophages (2 h ex vivo) released hydrogen peroxide at a rate of 3.5 +/- 1.3 nmol/min mg protein-1, which was a cyanide-sensitive process. H2O2 release from alveolar macrophages decreased slightly but not significantly after 1 day in hyperoxia and increased significantly after 3 days (180%, p less than .05) and 14 days… CONTINUE READING

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