Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor

@article{Matsushita2005HydrogenPR,
  title={Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor},
  author={Kenji Matsushita and Craig N. Morrell and Rebecca J.A. Mason and Munekazu Yamakuchi and Firdous Ahmad Khanday and Kaikobad Irani and Charles J Lowenstein},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={170},
  pages={73 - 79}
}
Although an excess of reactive oxygen species (ROS) can damage the vasculature, low concentrations of ROS mediate intracellular signal transduction pathways. We hypothesized that hydrogen peroxide plays a beneficial role in the vasculature by inhibiting endothelial exocytosis that would otherwise induce vascular inflammation and thrombosis. We now show that endogenous H(2)O(2) inhibits thrombin-induced exocytosis of granules from endothelial cells. H(2)O(2) regulates exocytosis by inhibiting N… CONTINUE READING