Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression.

@article{Barbosa2013HydrogenPP,
  title={Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression.},
  author={Marina Rodrigues Barbosa and Igor H Sampaio and Bruno Gonzaga Teodoro and Tha{\'i}s A. Sousa and Cl{\'a}udio C{\'e}sar Zoppi and Andr{\'e} Lu{\'i}s de Queiroz and Madla A Passos and Luciane Carla Alberici and Felipe Roberti Teixeira and Adriana Oliveira Manfiolli and Thiago Martins Batista and Ana Paula G Cappelli and Rosana In{\'a}cio Dos Reis and Dan{\'u}bia Frasson and Isis do Carmo Kettelhut and Lucas T. Parreiras-e-Silva and Cl{\'a}udio Miguel da Costa-Neto and Everardo Magalh{\~a}es Carneiro and R. A. Curi and Leonardo Dos Reis Silveira},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 10},
  pages={1591-604}
}
The mitochondrial redox state plays a central role in the link between mitochondrial overloading and insulin resistance. However, the mechanism by which the ROS induce insulin resistance in skeletal muscle cells is not completely understood. We examined the association between mitochondrial function and H2O2 production in insulin resistant cells. Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1… CONTINUE READING
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