Hydrogen peroxide production by monoamine oxidase during ischemia/reperfusion.

  title={Hydrogen peroxide production by monoamine oxidase during ischemia/reperfusion.},
  author={Oksana Kunduzova and Pascale Bianchi and Angelo Parini and Claudie Cambon},
  journal={European journal of pharmacology},
  volume={448 2-3},
Reactive oxygen species have been postulated to play a crucial role in the pathogenesis of renal ischemia-reperfusion injury. However, the intracellular sources of reactive oxygen species during ischemia-reperfusion are still unclear. In the present study, we examined whether catecholamine-degrading enzymes monoamine oxidases contribute to hydrogen peroxide (H(2)O(2)) generation during ischemia-reperfusion using an in vivo rat model of unilateral renal ischemia. The monoamine oxidases were… CONTINUE READING


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