Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells.

@article{Akaishi2004HydrogenPM,
  title={Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells.},
  author={Tatsuhiro Akaishi and Ken Nakazawa and Kaoru Sato and Hiroshi Saito and Yasuo Ohno and Yoshihisa Ito},
  journal={Neuroscience letters},
  year={2004},
  volume={356 1},
  pages={25-8}
}
Modification of voltage-gated Ca(2+) channels by hydrogen peroxide, a membrane-permeable form of reactive oxygen species, in cultured dentate granule cells was examined using the whole cell patch clamp technique. Pretreatment with hydrogen peroxide (1 and 10 microM) for 2 h enhanced the Ca(2+) current without affecting its voltage dependence. The enhancement was completely cancelled by 1 mM glutathione, an antioxidant, and 2 microM nifedipine, an L-type Ca(2+) channel blocker. In contrast, the… CONTINUE READING

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