Hydrogen peroxide mediates Rac1 activation of S6K1.

  title={Hydrogen peroxide mediates Rac1 activation of S6K1.},
  author={Gyu-Un Bae and Yong Kee Kim and Hyoung-Keun Kwon and Jong Woo Park and Eun Kyung Lee and Se Jin Paek and Wahn Soo Choi and In Duk Jung and Hoi Young Lee and Eun-Jung Cho and Hyang Woo Lee and Jeung-Whan Han},
  journal={Experimental cell research},
  volume={300 2},
We previously reported that hydrogen peroxide (H2O2) mediates mitogen activation of ribosomal protein S6 kinase 1 (S6K1) which plays an important role in cell proliferation and growth. In this study, we investigated a possible role of H2O2 as a molecular linker in Rac1 activation of S6K1. Overexpression of recombinant catalase in NIH-3T3 cells led to the drastic inhibition of H2O2 production by PDGF, which was accompanied by a decrease in S6K1 activity. Similarly, PDGF activation of S6K1 was… CONTINUE READING


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