Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.

@article{Okuda1996HydrogenPN,
  title={Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.},
  author={Sadatsugu Okuda and Nobuyoshi Nishiyama and Hiroyuki Saito and Hirohiko Katsuki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 22},
  pages={
          12553-8
        }
}
  • Sadatsugu Okuda, Nobuyoshi Nishiyama, +1 author Hirohiko Katsuki
  • Published 1996
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is markedly elevated under several pathological conditions, including Huntington disease and human immunodeficiency virus infection. Here we demonstrate that micromolar concentrations (1-100 microM) of 3-HK cause cell death in primary neuronal cultures prepared from rat striatum. The neurotoxicity of 3-HK was blocked by catalase and desferrioxamine but not by superoxide dismutase, indicating that the generation of… CONTINUE READING

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