Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.

Abstract

Gastric mucosal damage is directly associated with extracellular matrix degradation in which matrix metalloproteinases (MMPs) play a crucial role. Remodeling of connective tissues and loss of tissue integrity due to the action of MMPs are reported in several inflammatory diseases, including gastric ulcer. Indomethacin-induced gastric ulceration involves the… (More)

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@article{Ganguly2006HydrogenPD, title={Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.}, author={Krishnendu Ganguly and Parag Kundu and Aditi Banerjee and Russell J Reiter and Snehasikta Swarnakar}, journal={Free radical biology & medicine}, year={2006}, volume={41 6}, pages={911-25} }