Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells.

Abstract

Absence of the proapoptotic protein Bax renders tumor cells resistant to drug-induced apoptosis. We have shown that hydrogen peroxide (H(2)O(2))-mediated cytosolic acidification is an effector mechanism during drug-induced apoptosis of tumor cells. Here, we report that Bax is critical in determining the sensitivity of tumor cells to H(2)O(2)-induced… (More)
DOI: 10.1158/0008-5472.CAN-16-0230

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@article{Ahmad2004HydrogenPC, title={Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells.}, author={Kashif Adil Ahmad and Kartini Bte Iskandar and Jayshree L. Hirpara and Marie-V{\'e}ronique Cl{\'e}ment and Shazib Pervaiz}, journal={Cancer research}, year={2004}, volume={64 21}, pages={7867-78} }