Hydrogen peroxide is a novel inducer of connective tissue growth factor.

  title={Hydrogen peroxide is a novel inducer of connective tissue growth factor.},
  author={S. K. Park and Jae-Hong Kim and Young Seomun and Jungil Choi and Duk Hee Kim and Inn Oc Han and Eun Hui Lee and Sookja Kim Chung and Choun – Ki Joo},
  journal={Biochemical and biophysical research communications},
  volume={284 4},
Connective tissue growth factor (CTGF) has recently been described as a fibrogenic factor and is greatly induced by various extracellular stimuli, such as transforming growth factor-beta (TGF-beta), dexamethasone, and serotonin. CTGF induces collagen type I and fibronectin, and the deposition of such molecules leads to fibrotic disease in many tissues. Intracellular reactive oxygen species (ROS) are generated by extracellular stress conditions and are produced as by-products of cellular… CONTINUE READING
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