Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

@inproceedings{Chen2010HydrogenPI,
  title={Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells},
  author={Long Chen and Baoshan Xu and Lei Liu and Yan Luo and Jun Yin and Hongyu Zhou and Wenxing Chen and Tao Shen and Xiuzhen Han and Shile Huang},
  booktitle={Laboratory Investigation},
  year={2010}
}
Oxidative stress results in apoptosis of neuronal cells, leading to neurodegenerative disorders. However, the underlying molecular mechanism remains to be elucidated. Here, we show that hydrogen peroxide (H2O2), a major oxidant generated when oxidative stress occurs, induced apoptosis of neuronal cells (PC12 cells and primary murine neurons), by inhibiting the mammalian target of rapamycin (mTOR)-mediated phosphorylation of ribosomal p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E… CONTINUE READING
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