Hydrogen peroxide inhibits epidermal growth factor receptor internalization in human fibroblasts.

@article{Wit2000HydrogenPI,
  title={Hydrogen peroxide inhibits epidermal growth factor receptor internalization in human fibroblasts.},
  author={Rutger de Wit and Astrid A. Capello and Johannes Boonstra and Arie J. Verkleij and Jan Andries Post},
  journal={Free radical biology & medicine},
  year={2000},
  volume={28 1},
  pages={
          28-38
        }
}
Several cellular signal transduction cascades are affected by oxidative stress. In this study, the effect of hydrogen peroxide (H2O2) on the endocytosis of the epidermal growth factor (EGF) receptor was investigated. Exposure of HER14 cells to H2O2 resulted in a concentration-dependent inhibition of EGF receptor internalization. Binding studies demonstrated that this H2O2-induced inhibition in internalization was not due to altered binding of EGF to its receptor. Addition of H2O2 at different… CONTINUE READING
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