Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.

  title={Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.},
  author={Yunyan Kuang and Kumudha Balakrishnan and Varsha Gandhi and Xiaohua Peng},
  journal={Journal of the American Chemical Society},
  volume={133 48},
The major concern for anticancer chemotherapeutic agents is the host toxicity. The development of anticancer prodrugs targeting the unique biochemical alterations in cancer cells is an attractive approach to achieve therapeutic activity and selectivity. We designed and synthesized a new type of nitrogen mustard prodrug that can be activated by high level of reactive oxygen species (ROS) found in cancer cells to release the active chemotherapy agent. The activation mechanism was determined by… CONTINUE READING
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